Open an enzyme whose activation increases life expectancy
The issue of increasing life expectancy today is one of the main places in modern medicine. In the course of various investigations have achieved sufficient success in prolonging life in Drosophila flies, rodents, mammals and microorganisms, but the problem is that the person or one of the many ways does not work. However, as the newspaper writes EurekAlert, a group of researchers from the UK and the Netherlands has been able to find a universal enzyme that can extend life. Moreover, it is present in all living organisms.
"Magic" is the name of the enzyme RNA polymerase-III (Pol III). According to the results obtained in studies lifespan of yeast cells, flies and roundworms increased on average by 10% even with a slight decrease in activity Pol III and in adult animals. Thus it was previously thought that the enzyme RNA polymerase-III has no effect on the rate of aging. During the survey, experts have found that regardless of the method of inhibiting the enzyme (and the methods used are very different - mutagenesis by injection, RNA interference and other methods of editing enzyme activity), the result was positive in all living organisms. Also, we found out that Pol III enzyme are not only the lowest forms of life, but also mammals. Moreover, in mammals it is also in the active state, so a decrease in its activity can also help to increase life expectancy.