Genetic factors for obesity protects against diabetes

Some genetic variations associated with obesity may protect against type 2 diabetes, heart attack and stroke, researchers report. They believe that a place on the body where the body accumulates fat in the abdomen or around the liver, can be genetically predetermined. And the exact fat storage places have a value greater than the amount when it comes to insulin resistance and the risk of manifestation of diabetes and other diseases.

Genetic factors for obesity protects against diabetes

Scientists from Europe, including the Brunel University in London and the University of Exeter have identified 14 new genetic variants that determine where the body to store excess fat. Surprisingly, some of the genetic factors that increase obesity also reduce the metabolic risks.

The fat protects against diabetes?

"The storage of fat to diabetes risk point of view, plays an important role than the actual amount of fat," says geneticist Alex Blakemore. "There are some genetic factors increasing obesity, but, paradoxically, reducing metabolic risk. This is where the body fat stores. Immediately beneath the skin better than the surrounding organs or, especially around the liver. "

The researchers studied data from the British Biobank, collected from more than 500 000 people aged 37 to 73 years. MRI scans showed waists of these people, where they store excess fat, and allowed to draw parallels with the signs of type 2 diabetes, heart attack and stroke risks.

They found 14 genetic variations or changes in DNA associated with a higher BMI (body mass index), but a lower risk of developing diabetes, reduce blood pressure and risk of cardiovascular disease. So, when people gain weight, having these genetic factors, they store excess fat under the skin and less fat is stored in major organs such as the liver, pancreas and kidneys.

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