A new place of origin of blood cells in the human body
According to the edition of Cell Stem Cell, a team of researchers from the Columbia Center of translational immunology noticed a very interesting pattern a few years ago, many patients undergoing bowel transplantation, the body began to find a new area in which began the formation of blood. She was named "blood chimera", since it reproduces its own blood cells of the recipient, but on the basis of the donor tissue. Absorbed in the study of this phenomenon, the experts made a number of discoveries, which gave a better understanding of the physiology, which in the future will help to improve organ transplant procedure.
has long been known that the major site of production of blood cells is the bone marrow, but the opening of American Scientists says that the blood can be produced in cells of the intestine. And not only in people who have had organ transplants.
In the course of experts observed blood composition and phenotype of cells in 21 patients who received donor intestine for 5 years after surgery. As a result, hematopoietic stem cells and progenitor cells were found in the intestinal mucosa, Peyer's patches and mesenteric lymph nodes. Analysis of circulating after transplantation of donor T cells allowed to assume that they are a kind of "selection" in the lymphoid organs of the recipient for the acquisition of immunological tolerance. That is, the alien into the cells cease to be such and are attacked by its own immune system.
Schematic representation of process
"In our study we have demonstrated the link between the different blood cells. This process protects the graft from the effects of the immune system. "- said one of the authors of Megan Sykes.
At the moment, it is not known what kind of amount of blood is produced in the intestinal structures, but the researchers suggest that this figure may reach 10%. The new discovery will help better understand the immune system and to develop ways to protect organs from the effects of autoimmune reactions.
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