Australian scientists propose to treat dementia ultrasound
The next year will begin clinical trials of a promising new method of treating dementia and other neurodegenerative disorders associated with the accumulation of toxic proteins in the brain. Researchers from the University of Queensland have offered to remove these proteins with the help of ultrasound. In tests on laboratory animals show a new therapy is highly effective, the portal New Atlas.
Ultrasound therapy has been developed by scientists in 2015. Initial studies were aimed at finding ways to use ultrasonic waves to assist antibodies to quickly get to those proteins that are associated with the development of dementia and other neurodegenerative disorders. During the experiments, the scientists found that ultrasound effectively removes toxic plaques of amyloid protein from the brain without any additional therapeutic agents.
"The high speed of the ultrasonic waves oscillation activates microglial cells which are cleaved and removed by amyloid plaques, affecting the brain synapses. The word "breakthrough" is often misused, but in this case, our method is really fundamentally change our understanding of how to treat this disease. I see great potential in this form of therapy, "- noted as early as 2015 Jürgen Götz, a leading developer of a new method of ultrasonic treatment neyrodegenarativnyh diseases.
For several years, scientists engaged in laboratory tests of the new method, as well as improve it. They are injected into the brain of mice with dementia special microbubbles. When exposed to ultrasound brain completely restore lost cognitive function. Experiments involving sheep also proved the effectiveness of the approach. The team now plans to test the technique on people with Alzheimer's disease. Federal funding of $ 10 million dollars to allow for a trial involving 10 patients suffering from early forms of dementia. Clinical trials are planned to begin in 2019. According to researchers, ultrasound therapy will be most effective if you start treatment as early as possible - ideally before the first symptoms.
Scientists note that prior to the actual use of a new method for the treatment of dementia can take a few more years, but if clinical trials show it to be effective, then we may see a very simple way to deal with this disease. In an interview with Australian media Goetz noted that personal compact ultrasonic devices may appear in the future, which will allow to prevent development of the disease at the first sign of its manifestations.
"The long-term goal is to develop an affordable, portable device that can help millions of people with Alzheimer's disease not only in our country but around the world," - said Goetz.
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