Ancient viruses can beat cancer
The discovery of a universal cure for cancer has always been a fundamental goal of the doctors of the XXI century. According to the study, which was conducted at the Institute of them. Francis Crick, the DNA of the ancient virus particles can help the immune system to successfully identify and even to destroy tumors. In that case, how exactly way the next medical breakthroughs can happen?
Perhaps the medicine is on the threshold grand opening
Dormant viruses may help in the fight against cancer
Popular in the journal Genome Research scientific community argues that the fragments of human DNA contains traces of the so-called "endogenous retroviruses", which at the time brought a lot of trouble with our remote ancestors. For millions of years our ancestors were carriers of a countless number of different viruses, which led to the fact that information about them is in the DNA of modern man is now far exceeds the amount of information even about the man himself. It is known that about 8 percent of the human genome consists of viral DNA, while all known human genes account for only 1-2 percent.
See also: Some viruses are well affect the health At present, the viral DNA is dormant due to the fact that the human body for its existence, constantly exposed to evolutionary change, gradually increasing their resistance to various types of viruses. However, in the case where a cancerous cell is converted into a portion of some of its suppression mechanisms may fail, activating ancient viral DNA.
What are genes?
According to conventional wisdom, the genes represent a DNA fragments that contain full instructions for the production of proteins that perform most of the most important functions in the cell or organism as a whole. These instructions are transferred to an RNA molecule to yield protein. However, at the transcription process can affect DNA, the gene is located, which is used by some endogenous retroviruses.
a huge number of viral genes in the human genome is
In order to fully explore ways of interacting with the transcription of endogenous retroviruses, a team of scientists studied samples of patients suffering from 31 different types of cancer, using a special technology called "RNASeq", which is able to read even a short, seemingly random RNA fragments.
RNA view under the microscope
Focusing primarily on the study of transcripts specific to melanoma, the researchers used a material decoding algorithm in order to make it visible to the human immune system. As a result of the experiment, the researchers were able to detect 14 transcripts-potential candidates in 8 different areas of the human genome, are able to create unique antigens of cancer. Later, the researchers were able to narrow down their numbers, leaving only nine unique peptides, which can easily be detected by the immune system.
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If so, the study can form the basis for future advanced cancer treatments, which will include the original vaccination of the human immune system to recognize and attack cancer cells successfully.